A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model

Author:

Peter Antonia Sophia1,Roth Edith2,Schulz Sebastian R.2,Fraedrich Kirsten1,Steinmetz Tobit2,Damm Dominik1,Hauke Manuela2,Richel Elie1,Mueller‐Schmucker Sandra1,Habenicht Katharina3,Eberlein Valentina4,Issmail Leila4,Uhlig Nadja4,Dolles Simon5,Grüner Eva1,Peterhoff David67,Ciesek Sandra8910,Hoffmann Markus1112,Pöhlmann Stefan1112,McKay Paul F.13,Shattock Robin J.13,Wölfel Roman1415,Socher Eileen11617,Wagner Ralf6,Eichler Jutta5,Sticht Heinrich16,Schuh Wolfgang2,Neipel Frank1,Ensser Armin1,Mielenz Dirk2,Tenbusch Matthias1,Winkler Thomas H.3,Grunwald Thomas4,Überla Klaus1,Jäck Hans‐Martin2ORCID

Affiliation:

1. Institute of Clinical and Molecular Virology University Hospital Erlangen Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

2. Division of Molecular Immunology Internal Medicine III Nikolaus‐Fiebiger‐Center of Molecular Medicine Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

3. Division of Genetics Department Biology Nikolaus‐Fiebiger‐Center of Molecular Medicine Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

4. Department of Immunology Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig Germany

5. Department of Chemistry & Pharmacy Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

6. Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology) University of Regensburg Regensburg Germany

7. Institute of Clinical Microbiology and Hygiene University Hospital Regensburg Regensburg Germany

8. Institute of Medical Virology University Hospital Frankfurt Goethe University Frankfurt Frankfurt Germany

9. German Centre for Infection Research External Partner Site Frankfurt Germany

10. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Branch Translational Medicine and Pharmacology Frankfurt Germany

11. Infection Biology Unit German Primate Center Göttingen Germany

12. Faculty of Biology and Psychology Georg‐August‐University Göttingen Göttingen Germany

13. Department of Infectious Diseases Imperial College London London UK

14. Bundeswehr Institute of Microbiology Munich Germany

15. German Center for Infection Research Partner Site Munich Munich Germany

16. Division of Bioinformatics Institute of Biochemistry Emil‐Fischer Center Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

17. Institute of Anatomy, Functional and Clinical Anatomy Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference65 articles.

1. A Novel Coronavirus from Patients with Pneumonia in China, 2019

2. [Internet] Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.COVID‐19 Dashboard.2021[cited 2021 April 09] Available fromhttps://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6.

3. COVID-19 vaccines: where we stand and challenges ahead

4. SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

5. Estimating real‐world COVID‐19 vaccine effectiveness in Israel using aggregated counts;Aran D.;medRxiv,2021

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