Challenges with afucosylation content in antibody-based drugs: Guidance provided by mathematical modeling
Author:
Affiliation:
1. Dept. of Molecular Biochemistry & Biophysics; Yale University; New Haven CT
2. Chung Bioengineering Consulting and Mendocino College; Ukiah CA
Publisher
Wiley
Subject
Biotechnology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2056/fullpdf
Reference17 articles.
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3. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity;Shields;J Biol Chem,2002
4. The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity;Shinkawa;J Biol Chem,2003
5. Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA;Mori;Biotechnol Bioeng,2004
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Afucosylated Biosimilars need Afucosylation Specific Assays;MOJ Cell Science & Report;2017-11-30
2. General solutions to decompose heterogeneous compositions using antibody afucosylation as a model system;Biotechnology Progress;2017-01-10
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