Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia

Author:

Badar Talha1,Handisides Damian R.2,Benito Juliana M.1,Richie Mary Ann1,Borthakur Gautam1,Jabbour Elias1,Harutyunyan Karine1,Konoplev Sergej3,Faderl Stefan1,Kroll Stew2,Andreeff Michael14,Pearce Tillman2,Kantarjian Hagop M.1,Cortes Jorge E.1,Thomas Deborah A.1,Konopleva Marina14

Affiliation:

1. Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston Texas

2. Threshold Pharmaceuticals; South San Francisco California

3. Department of Hematopathology; The University of Texas MD Anderson Cancer Center; Houston Texas

4. Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston Texas

Funder

Threshold Pharmaceuticals

Merck KGaA, Darmstadt, Germany

NIH/NCI

Publisher

Wiley

Subject

Hematology

Reference33 articles.

1. Targeting hypoxia in cancer therapy;Wilson;Nat Rev Cancer,2011

2. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics;Semenza;Oncogene,2010

3. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases;Zhong;Cancer Res,1999

4. The influence of microenvironmental factors during cancer therapy;Durand;In Vivo,1994

5. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy;Gray;Br J Radiol,1953

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