Inhibition of connective tissue growth factor attenuates paraquat-induced lung fibrosis in a human MRC-5 cell line

Author:

Huang Min1,Yang Huifang1,Zhu Lingqin1,Li Honghui1,Zhou Jian1,Zhou Zhijun2

Affiliation:

1. The Department of Occupational and Environmental Health; School of Public Health; Ningxia Medical University; 750004, 1160 Shengli Street, Xingqing District Yinchuan 750004 People's Republic of China

2. School of Public Health; Key Lab of Public Health Safety; Ministry of Education; WHO Collaborating Center for Occupational Health, Fudan University; Shanghai 200032 China

Funder

The National Science Foundation of China

Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Reference34 articles.

1. Growth factors in idiopathic pulmonary fibrosis: Relative roles;Allen;Respir Res,2002

2. Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?;Blom;Matrix Biol,2002

3. Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo;Brigstock;J Cell Commun Signal,2009

4. JNK1/2 siRNA inhibits transforming-growth factor-β1-induced connective tissue growth factor expression and fibrotic function in THSFs;Chang;Mol Cel Biol,2010

5. Scratch-wound assay;Cory;Methods Mol Biol,2011

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