Affiliation:
1. Department of Cardiovascular Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
Abstract
AbstractBackgroundThe association between surgical treatment of mitral regurgitation (MR) and renal function is not sufficiently well‐known. We tried to evaluate renal function before and after the procedure of surgical mitral valve repair (SMVR) in degenerative severe MR.MethodsPatients with primary severe (4+) MR and normal left ventricular ejection fraction (LVEF) that underwent SMVR, examined by a cutting‐edge 3‐dimensional (3D) echocardiographic probe were enrolled in this study. We took three CKD‐EPI equations to measure estimated glomerular filtration rate (eGFR) before SMVR and shortly before patients discharge. A total of 40 patients with baseline lower mean eGFR were evaluated.ResultsMeasurements substantiated statistically significant improvements in eGFR (p < 0.001), multivariable linear regression modeling indicating prominent associations between increase in eGFR and decrease of MR (p = 0.003), decline of pulmonary arterial systolic pressure (p = 0.018), as well as increment of forward stroke volume (p = 0.02), in spite of LVEF reduction, left ventricular global longitudinal strain worsening and left atrial ejection fraction impairment.ConclusionsRenal function improves after SMVR in patients with degenerative significant MR and preserved LVEF, regardless of cardiac functional worsening.