Immune checkpoint inhibitors in hepatocellular carcinoma: A review of current clinical trials

Author:

Gamboa Adriana C.1ORCID,Kooby David A.2ORCID,Maithel Shishir K.2ORCID,Gamblin T. Clark3ORCID

Affiliation:

1. Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA

2. Department of Surgery, Division of Surgical Oncology Winship Cancer Institute Atlanta Georgia USA

3. Division of Surgical Oncology Medical College of Wisconsin Milwaukee Wisconsin USA

Abstract

AbstractHepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis due to advanced disease presentation or recurrence despite curative‐intent resection. Since the approval of sorafenib in 2007, few systemic therapies offered a significant improvement in treatment outcomes. Over the last 3 years, however, rapid advancements in the field of immunotherapy have led to approval of checkpoint inhibitors in 2020 for use in advanced HCC. Since then, a few other clinical trials have shown promising results in the adjuvant and neoadjuvant setting. The objective of this review is to summarize data from existing clinical trials evaluating the use of systemic immune checkpoint inhibitors in HCC and to follow the natural evolution of this development across the metastatic, adjuvant, and neoadjuvant landscapes.

Publisher

Wiley

Subject

Oncology,General Medicine,Surgery

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