Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: A children's oncology group study

Author:

Bagatell Rochelle1,Norris Robin2,Ingle Ashish M.3,Ahern Charlotte4,Voss Stephan5,Fox Elizabeth1,Little Anthony R.1,Weigel Brenda J.6,Adamson Peter C.1,Blaney Susan4

Affiliation:

1. The Children's Hospital of Philadelphia; Philadelphia Pennsylvania

2. Rainbow Babies and Children's Hospital; Cleveland Ohio

3. Children's Oncology Group Statistics and Data Center; Arcadia California

4. Texas Children's Cancer Center/Baylor College of Medicine; Houston Texas

5. Dana-Farber Cancer Institute/Children's Hospital Boston; Boston Massachusetts

6. University of Minnesota; Minneapolis Minnesota

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference32 articles.

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2. mTOR signaling and drug development in cancer;Dancey;Nat Rev Clin Oncol,2010

3. Molecular mechanisms of mTOR-mediated translational control;Ma;Nat Rev Mol Cell Biol,2009

4. Regulation of cap-dependent translation by eIF4E inhibitory proteins;Richter;Nature,2005

5. Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies;Barrett;Paediatr Drugs,2012

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