Challenges in the Development of Novel Cardiovascular Therapies

Author:

Hwang TJ1,Kesselheim AS1

Affiliation:

1. Program On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference5 articles.

1. Temporal trends and factors associated with cardiovascular drug development, 1990 to 2012;Hwang;J. Am. Coll. Cardiol. Basic Trans. Sci.,2016

2. Angiotensin-neprilysin inhibition versus enalapril in heart failure;McMurray;N. Engl. J. Med.,2014

3. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial;Nicholls;JAMA,2014

4. Cardiovascular drug development: is it dead or just hibernating?;Fordyce;J. Am. Coll. Cardiol.,2015

5. The roles of academia, rare diseases, and repurposing in the development of the most transformative drugs;Kesselheim;Health Affairs,2015

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