Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study

Author:

Oh Jaeseong1ORCID,Lee SeungHwan1,Kim Anhye2,Yoon Jangsoo1,Jang Kyungho3,Lee Doo H.4,Cho Sunyoung4,Lee Sang Rim4,Yu Kyung-Sang1,Chung Jae-Yong5

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine and Hospital; Seoul Republic of Korea

2. Clinical Trial Center; Ajou University Medical Center; Suwon Republic of Korea

3. Center for Clinical Pharmacology; Biomedical Research Institute; Chonbuk National University Hospital; Jeonju Republic of Korea

4. Vivozon, Inc.; Seoul Republic of Korea

5. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine and Bundang Hospital; Seongnam Republic of Korea

Funder

Vivozon, Inc.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects;Furlan;CMAJ,2006

2. Opioids and the treatment of chronic pain: controversies, current status, and future directions;Rosenblum;Exp Clin Psychopharmacol,2008

3. Current aproach to cancer pain management: availability and implications of different treatment options;Nersesyan;Ther Clin Risk Manag,2007

4. Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain;Dohi;Pharmacol Ther,2009

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