Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials

Author:

Zhang Zhiwei1,Wang Chenguang2,Troendle James F.3

Affiliation:

1. Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health; US Food and Drug Administration; Silver Spring MD U.S.A.

2. Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine; Baltimore MD U.S.A.

3. Office of Biostatistics Research, Division of Cardiovascular Sciences; National Heart, Lung and Blood Institute, National Institutes of Health; Bethesda MD U.S.A.

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference33 articles.

1. Interpreting tests for efficacy in clinical trials with multiple endpoints;O'Brien;Controlled Clinical Trials,1997

2. Efficacy endpoint selection and multiplicity adjustment methods in clinical trials with inherent multiple endpoint issues;Sankoh;Statistics in Medicine,2003

3. A simple sequentially rejective multiple test procedure;Holm;Scandinavian Journal of Statistics,1979

4. An improved Bonferroni procedure for multiple tests of significance;Simes;Biometrika,1986

5. A sharper Bonferroni procedure for multiple tests of significance;Hochberg;Biometrika,1988

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