Correlates of resistance and relapse during blinatumomab therapy for relapsed/refractory acute lymphoblastic leukemia

Author:

Aldoss Ibrahim1,Song Joo2,Stiller Tracey3,Nguyen Tina4,Palmer Joycelynne3,O'Donnell Margaret1,Stein Anthony S.1,Marcucci Guido1,Forman Stephen1,Pullarkat Vinod1ORCID

Affiliation:

1. Department of Hematology and Hematopoietic Cell Transplantation; Gehr Family Center for Leukemia Research, City of Hope Medical Center; Duarte California

2. Department of Information Sciences, Division of Biostatistics; City of Hope Medical Center; Duarte California

3. Department of Pathology; City of Hope Medical Center; Duarte California

4. Department of Pharmacy; City of Hope Medical Center; Duarte California

Publisher

Wiley

Subject

Hematology

Reference19 articles.

1. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study;Topp;Lancet Oncol.,2015

2. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia;Topp;JCO.,2014

3. Immunotherapy delivered by Blinatumomab improves survival in acute lymphoblastic leukaemia patients;Topp;Haematologica.,2016

4. Pharmacokinetics/pharmacodynamics (PKPD) of blinatumomab in patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (r/r ALL);Zhu;J Clin Oncol.,2015

5. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab;Klinger;Blood.,2012

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