Newborn auditory brainstem response and sudden infant death syndrome

Author:

Maylott Sarah E.1ORCID,Zeng Guangyu2ORCID,Leung Tiffany S.3ORCID,Montenegro Catalina Sanchez3ORCID,Barrios Alexia4ORCID,Malik Arushi3ORCID,Delgado Rafael E.356ORCID,Delgado Christine F.3ORCID,Simpson Elizabeth A.3ORCID

Affiliation:

1. Department of Psychiatry Duke University Durham North Carolina USA

2. Division of Applied Psychology The Chinese University of Hong Kong Shenzhen China

3. Department of Psychology University of Miami Coral Gables Florida USA

4. University of Miami Miller School of Medicine Coral Gables Florida USA

5. Biomedical Engineering University of Miami Coral Gables Florida USA

6. Intelligent Hearing Systems Corp. Miami Florida USA

Abstract

AbstractSudden infant death syndrome (SIDS)—the sudden and unexplained death of a seemingly healthy infant, <1 year old—may be associated with abnormalities in the brain regions that underlie breathing and arousal during sleep. While post‐mortem studies suggest abnormalities in SIDS infants' brainstems, there are no studies of these infants' brainstem function before death. One way to assess the function of the brainstem is with auditory brainstem response (ABR), a routine hearing‐screening method that noninvasively measures the brainstem's response to sound. We hypothesize that anomalies in newborns' ABR measures may predict SIDS. Indeed, previous studies identified abnormalities in ABR characteristics in small samples of near‐miss SIDS infants hospitalized for infant apnea syndrome. However, there is a need to examine the ABRs of infants who died of SIDS. Therefore, in the current study, we propose integrating two secondary datasets to examine newborns' ABRs (N = 156,972), including those who later died of SIDS (n = ~42; .27 out of every 1000 infants), using existing archived records of neonatal ABR results from a sample of newborns born in Florida. We hypothesize that infants who die from SIDS are more likely than non‐SIDS infants to have abnormal ABRs as newborns. Understanding the association between SIDS and ABR may facilitate more accurate identification of an infant's risk for SIDS at birth, enabling increased monitoring, which may facilitate interventions and improve survivorship.

Publisher

Wiley

Reference67 articles.

1. Association of maternal smoking and other risk factors with sudden infant death syndrome (SIDS);Asif F.;Journal of Society of Prevention, Advocacy and Research KEMU,2023

2. The factors contributing to the risk of sudden infant death syndrome;Athanasakis E.;Hippokratia,2011

3. Auditory Nerve and Brain Stem Responses to Sound Stimuli at Various Frequencies

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