Affiliation:
1. Universidad del Rosario Bogota Colombia
2. Johns Hopkins University Baltimore Maryland
3. Johns Hopkins Bloomberg School of Public Health Baltimore Maryland
4. Cedars‐Sinai Medical Center Los Angeles California
Abstract
ObjectiveThe gastrointestinal (GI) tract is commonly affected in systemic sclerosis (SSc). A positive association between antivinculin antibody levels and GI symptom severity is reported in SSc. We sought to examine whether antivinculin antibodies associate with measures of GI dysmotility and extraintestinal clinical phenotype in SSc.MethodsA total of 88 well‐characterized patients with SSc and GI disease were assayed for antivinculin antibodies by enzyme‐linked immunosorbent assay. Whole‐gut scintigraphy, GI symptom scores, and clinical features of SSc were compared between patients with and without antibodies.ResultsTwenty of 88 (23%) patients had antivinculin antibodies, which were more prevalent in patients with slow gastric transit (35% versus 22%). In the univariate analyses, patients who were positive for antivinculin antibodies were more likely to have limited cutaneous disease (odds ratio [OR] 9.60 [95% confidence interval (95% CI) 1.19, 77.23]) and thyroid disease (OR 4.09 [95% CI 1.27, 13.21]). Such patients were also less likely to have lung involvement based on a Medsger Severity Score of ≥2 (OR 0.25 [95% CI 0.07, 0.92]). Higher levels of antivinculin autoantibodies were associated with less gastric emptying (β coefficient –3.41 [95% CI –6.72, –0.09]). The association between antivinculin antibodies and each of these clinical features remained significant in the multivariable model. In particular, the presence of antivinculin antibodies (β coefficient –6.20 [95% CI –12.33, –0.063]) and higher levels of antivinculin antibodies (β coefficient –3.64 [95% CI –7.05, –0.23]) were each significantly associated with slower gastric transit.ConclusionAntivinculin antibodies associate with slower gastric transit in SSc and may provide insight into GI complications of SSc.image
Funder
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Rheumatology Research Foundation
Scleroderma Research Foundation
Cited by
2 articles.
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