The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in themdr1a gene
Author:
Publisher
Wiley
Subject
Health, Toxicology and Mutagenesis,Toxicology,Molecular Biology,Molecular Medicine,Biochemistry,General Medicine
Reference19 articles.
1. BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER
2. The physiological function of drug-transporting P-glycoproteins
3. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.
4. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
5. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.
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