Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives

Author:

Schmidt Simone K.1,Höfner Georg1,Wanner Klaus T.1

Affiliation:

1. Department of Pharmacy - Center of Drug Research; Ludwig-Maximilians-Universität München; Munich Germany

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference24 articles.

1. Four different subtypes of membrane-bound GABA transport proteins are known, whereas their nomenclature is species-dependent. Murine subtypes were indicated as mGAT1-mGAT4 corresponding to hGAT-1, hBGT-1, hGAT-2, and hGAT-3 in humans, respectively. In the following, the nomenclature for the murine systems is employed

2. GABA uptake inhibitors: relevance to antiepileptic drug research;Krogsgaard-Larsen;Epilepsy Res.,1987

3. Different binding modes of small and large binders of GAT1;Wein;ChemMedChem,2016

4. Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4;Kragler;Eur J Med Chem,2008

5. Development of an (S)-1-{2-[Tris(4-methoxyphenyl)-methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4;Pabel;ChemMedChem,2012

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