Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver-Reference-Cited by-同舟云学术

Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver

Published:2017-01-23 Issue:7 Volume:31 Page:e21902
ISSN:1095-6670
Container-title:Journal of Biochemical and Molecular Toxicology
language:en
Short-container-title:J Biochem Mol Toxicol

Author:

Wang Liupeng¹,Xu Wenwei²,Ma Leilei¹,Zhang Suxing³,Zhang Kezhi³,Ye Peizhen³,Xing Guozhen⁴,Zhang Xuefeng⁴,Cao Yiyi¹,Xi Jing¹,Gu Jun⁵,Luan Yang¹

Affiliation:

1. Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health; Shanghai Jiao Tong University School of Medicine; Shanghai 200025 People's Republic of China

2. Tong Ren Hospital Affiliated To Shanghai Jiao Tong University School of Medicine; Shanghai 200336 People's Republic of China

3. KG Pharma Limited; Foshan 528000 People's Republic of China

4. Jiangsu Tripod Preclinical Research Laboratories; Pukou Economic Development Zone; Nanjing People's Republic of China

5. Wadsworth Center; New York State Department of Health; Albany NY 12201-0509 USA

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Toxicology,Molecular Biology,Molecular Medicine,Biochemistry,General Medicine

Reference37 articles.

1. Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1

2. Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity

3. Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

4. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

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