Neutrophils recruit regulatory T-cells into tumorsviasecretion of CCL17-A new mechanism of impaired antitumor immunity

Author:

Mishalian Inbal1,Bayuh Rachel1,Eruslanov Evgeniy2,Michaeli Janna1,Levy Liran1,Zolotarov Lida1,Singhal Sunil2,Albelda Steven M.2,Granot Zvi3,Fridlender Zvi G.12

Affiliation:

1. Institute of Pulmonary Medicine; Hadassah-Hebrew University Medical Center; Jerusalem Israel

2. Thoracic Oncology Research Laboratory; University of Pennsylvania; Philadelphia PA

3. Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada; The Hebrew University-Hadassah Medical School; Jerusalem Israel

Funder

Israel Cancer Research Fund

Israel Lung Association

Israel Ministry of Health

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference39 articles.

1. Tumor-associated neutrophils: friend or foe?;Fridlender;Carcinogenesis,2012

2. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression;Piccard;Crit Rev Oncol Hematol,2012

3. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients;Schmielau;Cancer Res,2001

4. Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN;Fridlender;Cancer Cell,2009

5. Inhibition of tumor growth by elimination of granulocytes;Pekarek;J Exp Med,1995

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