Gamma‐secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF‐κB signaling pathway induced by IL‐1β and TNF‐α in nucleus pulposus cells-Reference-Cited by-同舟云学术

Gamma‐secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF‐κB signaling pathway induced by IL‐1β and TNF‐α in nucleus pulposus cells

Published:2018-10-26 Issue:2 Volume:120 Page:1903-1915
ISSN:0730-2312
Container-title:Journal of Cellular Biochemistry
language:en
Short-container-title:J Cell Biochem

Author:

Huang Yao¹^ORCID,Mei Wei²,Chen Jian³,Jiang Tao⁴,Zhou Zheng³,Yin Guoyong³,Fan Jin³

Affiliation:

1. Department of Orthopaedics Institute of Sport Medicine, Affiliated Hospital of Nanjing University of TCM Nanjing China

2. Department of Orthopaedics Institute of Traumatology Department, Affiliated Hospital of Nanjing University of TCM Nanjing China

3. Department of Orthopaedics The First Affiliated Hospital of Nanjing Medical University Nanjing China

4. Department of Orthopedics Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.27504

Reference24 articles.

1. Acute and Chronic Low Back Pain

2. Interleukin-1β in intervertebral disk degeneration

3. IL-20 May Contribute to the Pathogenesis of Human Intervertebral Disc Herniation

4. Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

5. Immunomorphological Analysis of RAGE Receptor Expression and NF- B Activation in Tissue Samples from Normal and Degenerated Intervertebral Discs of Various Ages

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