Affiliation:
1. Department of Biomedical Engineering City University of Hong Kong Kowloon Tong Hong Kong
2. Hong Kong Center for Cerebra‐Cardiovascular Health Engineering Hong Kong Science Park New Territories Hong Kong
3. Department of Biomedical Engineering Hong Kong Polytechnic University Kowloon Hong Kong
4. Leshan Hospital of Traditional Chinese Medicine Leshan China
Abstract
AbstractSepsis is a severe organ dysfunction typically caused by wound infection which leads to septic shock, organ failure or even death if no early diagnosis and property medical treatment were taken. Herein, we report a soft, wearable and battery‐free wound dressing system (WDS) for wireless and real‐time monitoring of wound condition and sepsis‐related biomarker (procalcitonin [PCT]) in wound exudate for early sepsis detection. The battery‐free WDS powered by near‐field communication enables wireless data transmission, signal processing and power supply, which allows portable intelligent wound caring. The exudate collection associates with soft silicone based microfluidic technologies (exudate collection time within 15 s), that can filtrate contamination at the cell level and enable a superior filtration rate up to 95% with adopting microsphere structures. The battery‐free WDS also includes state‐of‐the‐art biosensors, which can accurate detect the pH value, wound temperature, and PCT level and thus for sepsis diagnosis. In vivo studies of SD rats prove the capability of the WDS for continuously monitoring wound condition and PCT concentration in the exudate. As a result, the reported fully integrated WDS provides a potential solution for further developing wearable, multifunctional and on‐site disease diagnosis.
Funder
City University of Hong Kong
Foundation for Angelman Syndrome Therapeutics
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biotechnology
Cited by
4 articles.
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