Affiliation:
1. Chemical Research Department APL Research Centre‐II, Aurobindo Pharma Ltd. Sangareddy District Telangana India
2. Department of Chemistry Acharya Nagarjuna University Guntur Andhra Pradesh India
Abstract
AbstractAmlodipine belongs to the class of calcium channel blocker that is used to reduce high blood pressure (hypertension). Two related substances of amlodipine namely 3‐(2‐[1.3‐dioxo‐1,3‐dihydro‐2H‐isoindol‐2‐yl]ethyl)‐5‐methyl‐(4RS)‐4(2‐chlorophenyl)‐2‐([2‐(1,3‐dioxo‐1,3‐dihydro‐2H‐isoin‐dol‐2‐yl)ethoxy]methyl)‐6‐methyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate (11) and 3‐([2‐aminoethyl]‐5‐aminoethoxy)‐4‐(2‐chlorophenyl)‐1,4‐dihydro‐6‐methylpyridine‐3,5‐dicarboxylate (12) were identified. The present work describes the origin, synthesis, and characterization of these related substances.