Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes-Reference-Cited by-同舟云学术

Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes

Published:2023-08-30 Issue:1 Volume:40 Page:
ISSN:1520-7552
Container-title:Diabetes/Metabolism Research and Reviews
language:en
Short-container-title:Diabetes Metabolism Res

Author:

Onengut‐Gumuscu Suna¹^ORCID,Webb‐Robertson Bobbie‐Jo M.²³,Sarkar Soumyadeep²,Manichaikul Ani¹,Hu Xiaowei¹^ORCID,Frazer‐Abel Ashley⁴,Holers V. Michael⁵,Rewers Marian J.⁶,Rich Stephen S.¹

Affiliation:

1. Center for Public Health Genomics University of Virginia Charlottesville Virginia USA

2. Biological Sciences Division Pacific Northwest National Laboratory Richland Washington USA

3. Colorado School of Public Health University of Colorado Anschutz Medical Campus Aurora Colorado USA

4. Exsera BioLabs Division of Rheumatology University of Colorado School of Medicine Aurora Colorado USA

5. Division of Rheumatology Department of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA

6. Barbara Davis Center for Diabetes School of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA

Abstract

AbstractType 1 diabetes is an autoimmune disease in which one's own immune system destroys insulin‐secreting beta cells in the pancreas. This process results in life‐long dependence on exogenous insulin for survival. Both genetic and environmental factors play a role in disease initiation, progression, and ultimate clinical diagnosis of type 1 diabetes. This review will provide background on the natural history of type 1 diabetes and the role of genetic factors involved in the complement system, as several recent studies have identified changes in levels of these proteins as the disease evolves from pre‐clinical through to clinically apparent disease.

Funder

Leona M. and Harry B. Helmsley Charitable Trust

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dmrr.3716

Reference48 articles.

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2. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group.

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