Affiliation:
1. Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czechia
Abstract
The synthesis of tritium‐labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in‐house prepared tritium‐labelled alkylating agent ([3H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
Funder
Akademie Věd České Republiky