Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1-Reference-Cited by-同舟云学术

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1

Published:2015-04-22 Issue:10 Volume:62 Page:1709-1716
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatr Blood Cancer

Author:

Jousma Edwin¹,Rizvi Tilat A.¹,Wu Jianqiang¹,Janhofer David²,Dombi Eva²,Dunn Richard S.³,Kim Mi-Ok⁴,Masters Andrea R.⁵,Jones David R.⁶,Cripe Timothy P.⁷,Ratner Nancy¹

Affiliation:

1. Division of Experimental Hematology and Cancer Biology; Children's Hospital Medical Center; Cincinnati Ohio

2. Pediatric Oncology Branch; National Cancer Institute; Bethesda Maryland

3. Division of Imaging Resource Center; Children's Hospital Medical Center; Cincinnati Ohio

4. Department of Pediatrics; Biostatistics and Epidemiology; Cincinnati Children's Hospital Medical Center; Cincinnati Ohio

5. Simon Cancer Center; Indiana University School of Medicine; Indianapolis Indiana

6. Department of Medicine; Division of Clinical Pharmacology; Indiana University School of Medicine; Indianapolis Indiana

7. Center for Childhood Cancer and Blood Diseases; Nationwide Children's Hospital; Columbus Ohio

Funder

Children's Tumor Foundation

NTAP

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pbc.25546/fullpdf

Reference39 articles.

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2. Clinical and genetic aspects of neurofibromatosis 1;Jett;Genet Med,2010

3. Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects;Messiaen;Hum Mutat,2000

4. GTPase activating proteins: Critical regulators of intracellular signaling;Donovan;Biochim Biophys Acta,2002

5. Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients;Maertens;Hum Mol Genet,2006

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