Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation-Reference-Cited by-同舟云学术

Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation

Published:2023-06-26 Issue:9 Volume:38 Page:1736-1742
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Movement Disorders

Author:

Koy Anne¹^ORCID,Kühn Andrea A.²,Schiller Petra³,Huebl Julius²⁴,Schneider Gerd‐Helge⁵,Eckenweiler Matthias⁶,Rensing‐Zimmermann Cornelia⁶,Coenen Volker Arnd⁷⁸,Krauss Joachim K.⁹^ORCID,Saryyeva Assel⁹,Hartmann Hans¹⁰,Lorenz Delia¹¹,Volkmann Jens¹²,Matthies Cordula¹³,Schnitzler Alfons¹⁴¹⁵,Vesper Jan¹⁶,Gharabaghi Alireza¹⁷,Weiss Daniel¹⁸,Bevot Andrea¹⁹,Marks Warren²⁰²¹,Howser Angela²¹,Monbaliu Elegast²²,Mueller Joerg²³,Prinz‐Langenohl Reinhild²⁴,Visser‐Vandewalle Veerle²⁵,Timmermann Lars²⁶,

Affiliation:

1. Department of Pediatrics Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany

2. Department of Neurology Charité University Medicine Berlin Berlin Germany

3. Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

4. Department of Neurology Munich Municipal Hospital Bogenhausen Munich Germany

5. Department of Neurosurgery Charité University Medicine Berlin Germany

6. Department of Neuropediatrics and Muscle Disorders University Medical Center, Faculty of Medicine, University of Freiburg Freiburg Germany

7. Department of Stereotactic and Functional Neurosurgery University Medical Center, Faculty of Medicine, University of Freiburg Freiburg Germany

8. Center for Deep Brain Stimulation University Medical Center Freiburg Germany

9. Department of Neurosurgery Hannover Medical School Hannover Germany

10. Clinic for Pediatric Kidney, Liver and Metabolic Diseases Hannover Medical School Hannover Germany

11. Department of Pediatrics University Children's Hospital Wuerzburg Germany

12. Department of Neurology University Hospital Würzburg Würzburg Germany

13. Department of Stereotactic and Functional Neurosurgery University Hospital Würzburg Würzburg Germany

14. Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich Heine University Düsseldorf Düsseldorf Germany

15. Department of Neurology, Medical Faculty Heinrich Heine University Düsseldorf Düsseldorf Germany

16. Department of Functional Neurosurgery and Stereotaxy, Medical Faculty Heinrich Heine University Düsseldorf Düsseldorf Germany

17. Institute for Neuromodulation and Neurotechnology, Department of Neurosurgery and Neurotechnology University Hospital and University of Tübingen Tübingen Germany

18. Department of Neurology, Medical Faculty University of Tübingen Tübingen Germany

19. Department of Pediatric Neurology and Developmental Medicine University Children's Hospital Tübingen Tübingen Germany

20. Department of Neurology, Cook Children's Medical Center Fort Worth Texas USA

21. Department of Pediatrics University of North Texas Health Sciences Center Fort Worth Texas USA

22. Department of Rehabilitation Sciences KU Leuven Campus Bruges Brugge Belgium

23. Department of Neurology Vivantes Klinikum Spandau Berlin Germany

24. Clinical Trials Center Cologne Cologne Germany

25. Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

26. Department of Neurology University Hospital of Marburg Marburg Germany

Abstract

ABSTRACTBackgroundDeep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long‐term effects and the safety profile are rare.ObjectivesWe assessed the efficacy and safety of pallidal DBS in pediatric patients with DCP.MethodsThe STIM‐CP trial was a prospective, single‐arm, multicenter study in which patients from the parental trial agreed to be followed‐up for up to 36 months. Assessments included motor and non‐motor domains.ResultsOf the 16 patients included initially, 14 (mean inclusion age 14 years) were assessed. There was a significant change in the (blinded) ratings of the total Dyskinesia Impairment Scale at 36 months. Twelve serious adverse events (possibly) related to treatment were documented.ConclusionDBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Funder

Boston Scientific Corporation

Universität zu Köln

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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