Promoters influence the kinetics of transgene expression following adenovector gene delivery
Author:
Publisher
Wiley
Subject
Genetics(clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jgm.1127/fullpdf
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1. Neural-Targeted Gene Therapy for Rodent and Primate Hemiparkinsonism
2. Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.
3. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
4. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.
5. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.
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