Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations

Author:

Kunz Cornelia U.1,Stallard Nigel1,Parsons Nicholas1,Todd Susan2,Friede Tim3

Affiliation:

1. Warwick Medical School; University of Warwick; Gibbet Hill Coventry CV4 7AL UK

2. Department of Mathematics and Statistics; University of Reading; Whiteknights PO Box 220, Reading RG6 6AX UK

3. Department of Medical Statistics; University Medical Center Goettingen; Humboldtallee 32 D-37073 Goettingen Germany

Funder

Seventh Framework Programme

Medical Research Council

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability

Reference32 articles.

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2. Internal pilot studies for estimating sample size;Birkett;Statistics in Medicine,1994

3. Blinded sample size adjustment;Bristol;Drug Information Journal,2001

4. Challenge of multiple co-primary endpoints: a new approach;Chuang-Stein;Statistics in Medicine,2007

5. Exact test size and power of a Gaussian error linear model for an internal pilot study;Coffey;Statistics in Medicine,1999

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