Selection of composite binary endpoints in clinical trials

Author:

Bofill Roig Marta1ORCID,Gómez Melis Guadalupe1ORCID

Affiliation:

1. Department of Statistics and Operations Research; Universitat Politècnica de Catalunya; 08034 Barcelona Spain

Funder

Ministerio de Economía y Competitividad

Departament d'Economia i Coneixement de la Generalitat de Catalunya

Secretaría de Estado de Investigación, Desarrollo e Innovación

Agència de Gestió d’Ajuts Universitaris i de Recerca

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability

Reference15 articles.

1. Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns;Ferreira-González;Journal of Clinical Epidemiology,2007

2. The asymptotic relative efficiency and the ratio of sample sizes when testing two different null hypotheses;Gómez;SORT,2014

3. Statistical considerations when using a composite endpoint for comparing treatment groups;Gómez;Statistics in Medicine,2013

4. Global tests for multiple binary outcomes;Lefkopoulou;Biometrics,1993

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