Affiliation:
1. Department of Cytology & Gynecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India
2. Department of Pediatrics (Hematology‐Oncology division) Postgraduate Institute of Medical Education and Research Chandigarh India
3. Department of Histopathology Postgraduate Institute of Medical Education and Research Chandigarh India
Abstract
AbstractPilomatrixoma is a relatively rare benign skin appendageal tumor, often presenting in the pediatric age group as a nodular lesion and most commonly involving the head and neck, making it amenable to primary fine needle aspiration (FNA) diagnosis. We report the clinical and histopathological findings of two cases of pilomatrixoma in children, both of which were initially misdiagnosed as small round blue cell tumors due to high cellularity and misinterpretation of the proliferating basaloid cells. Histopathology revealed basal cell proliferation and mitoses indicating that they were progressive, early lesions. The first case showed membranous positivity for CD99 which prompted a diagnosis of Ewing sarcoma. Awareness of the morphological spectrum including positivity for CD99 and careful evaluation of cell block histology could have averted the misdiagnosis. Pilomatrixoma should be included as an important differential diagnosis when faced with primitive‐appearing cells on FNA, especially in children with mass lesions in the head and neck region.
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Cited by
1 articles.
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