Affiliation:
1. State Key Laboratory of Pharmaceutical Biotechnology National Institute of Healthcare Data Science at Nanjing University Jiangsu Key Laboratory of Molecular Medicine Medicine Medical School of Nanjing University Nanjing University Nanjing China
2. Microecological, Regenerative and Microfabrication Technical Platform for Biomedicine and Tissue Engineering Jinan Microecological Biomedicine Shandong Laboratory Jinan City China
Abstract
AbstractHypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy. Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells. A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. In this review, we discuss the critical role of hypoxia in tumor development, including tumor metabolism, tumor immunity, and tumor angiogenesis. The treatment methods for hypoxic TME are summarized, including hypoxia‐targeted therapy and improving oxygenation by alleviating tumor hypoxia itself. Hyperoxia therapy can be used to improve tissue oxygen partial pressure and relieve tumor hypoxia. We focus on the underlying mechanisms of hyperoxia and their impact on current cancer therapies and discuss the prospects of hyperoxia therapy in cancer treatment.
Funder
National Natural Science Foundation of China
Subject
Cell Biology,Biochemistry (medical),Genetics (clinical),Computer Science Applications,Drug Discovery,Genetics,Oncology,Immunology and Allergy
Cited by
16 articles.
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