1. Department of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo 060‐8543 Japan
2. Department of Cardiology Gifu University Graduate School of Medicine Gifu Japan
3. Department of Public Health Sapporo Medical University School of Medicine Sapporo Japan
4. Department of Pharmacology Sapporo Medical University School of Medicine Sapporo Japan
5. Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Hokkaido University of Science Sapporo Japan