Mimickers of neuroendocrine tumors on endoscopic ultrasound‐guided fine‐needle aspirate material: Need for caution

Author:

Wang Brant G.123ORCID,Li Wenping1,Lee Iris H.4,Mani Haresh1

Affiliation:

1. Department of Pathology Inova Fairfax Hospital Falls Church Virginia USA

2. School of Medicine Inova Campus University of Virginia Falls Church Virginia USA

3. Department of Pathology Georgetown University Medical Center Washington DC USA

4. Division of Gastroenterology, Department of Medicine Inova Fairfax Hospital Falls Church Virginia USA

Abstract

AbstractCytologic diagnosis of neuroendocrine tumors can be straightforward on cytologic preparations, given the classical neuroendocrine morphology and expression of neuroendocrine markers confirmed by immunohistochemistry. However, overreliance on neuroendocrine markers can lead to misdiagnosis even if individual cell features suggest a neuroendocrine tumor. We present three unusual cases, two of which were initially diagnosed as neuroendocrine tumors and the third one carried preliminary diagnosis of neuroendocrine tumor on endoscopic ultrasound‐guided fine‐needle aspirates. These cases subsequently turned out to be cholangioblastic cholangiocarcinoma, metastatic melanoma, and gastric glomus tumor, respectively. We suggest approaches that could have pointed us towards the correct diagnosis at the outset and discuss potential pitfalls.

Publisher

Wiley

Subject

General Medicine,Histology,Pathology and Forensic Medicine

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