Association between hepcidin levels and inflammatory bowel disease: A systematic review and meta‐analysis of observational studies

Author:

Soltanieh Samira1,Salavatizadeh Marieh1,Gaman Mihnea‐Alexandru2,Kord Varkaneh Hamed3ORCID,Tan Shing Cheng4,Prabahar Kousalya5,Lozovanu Oana Deliu6,Santos Heitor O.7,Hekmatdoost Azita1ORCID

Affiliation:

1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran

2. Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania & Department of Hematology, Centre of Hematology and Bone Marrow Transplantation Fundeni Clinical Institute Bucharest Romania

3. Department of Nutrition and Food Hygiene, Nutrition Health Research Center Hamadan University of Medical Sciences Hamadan Iran

4. UKM Medical Molecular Biology Institute Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia

5. Department of Pharmacy Practice, Faculty of Pharmacy University of Tabuk Tabuk Saudi Arabia

6. University of Normandie Caen France

7. School of Medicine Federal University of Uberlandia (UFU) Uberlandia Brazil

Abstract

AbstractHepcidin has a crucial role in iron homeostasis upon inflammatory conditions such as inflammatory bowel disease (IBD). Thus, we conducted a systematic review and meta‐analysis to determine the overall association between serum hepcidin concentrations and IBD. Based on the preferred reporting items for systematic review and meta‐analysis (PRISMA) protocols, an electronic literature search was conducted on PubMed/MEDLINE, Scopus, and Web of Science until June 2020. Studies were deemed eligible for inclusion if they met the following criteria: (1) diagnosis of IBD, (2) observational design, and (3) measured serum hepcidin and prohepcidin concentrations in IBD patients and control group. Overall, 10 studies including 1184 participants were evaluated. Random‐effects meta‐analysis revealed that subjects with IBD had 7.22 ng/mL (95% CI: 2.10, 12.34; p = .006) higher serum hepcidin concentrations compared to control groups. A nonsignificantly lower serum prohepcidin concentration (0.522 ng/mL, 95% CI: −1.983 to 0.939; p = .484) was found for IBD patients compared to healthy subjects. However, there was significant heterogeneity among the studies regarding both hepcidin (I2 = 98%, p < .001) and prohepcidin levels (I2 = 96%, p < .001), respectively. In an age‐based subgroup analysis, patients aged ≥18 years with IBD displayed higher serum hepcidin levels when compared to healthy individuals (22.36 ng/mL, 95% CI, 2.12–42.61; p = .030). Hepcidin concentrations are elevated in subjects with IBD; however, the clinical relevance of this finding requires further evaluation in future investigations as the increase is relatively small compared to the wide range of normal hepcidin values.

Funder

Shahid Beheshti University of Medical Sciences

Publisher

Wiley

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