TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model

Author:

Green Alanna C12ORCID,Lath Darren12,Hudson Katie12,Walkley Brant3ORCID,Down Jennifer M12,Owen Robert4,Evans Holly R12,Paton‐Hough Julia12,Reilly Gwendolen C4,Lawson Michelle A12ORCID,Chantry Andrew D125

Affiliation:

1. Sheffield Myeloma Research Team, Department of Oncology and MetabolismMedical School, University of Sheffield Sheffield UK

2. Mellanby Centre for Bone ResearchUniversity of Sheffield Medical School, University of Sheffield Sheffield UK

3. Department of Materials Science and EngineeringThe University of Sheffield Sheffield UK

4. INSIGNEO Institute of In Silico Medicine, Department of Materials Science and EngineeringUniversity of Sheffield Sheffield UK

5. Department of HaematologySheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital Sheffield UK

Funder

Bloodwise

Sheffield Hospitals Charity

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference73 articles.

1. Cancer Research UK. Myeloma statistics [Internet]. London UK: Cancer Research UK; no date [cited 2019 Sep 8]. Available from:http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/myeloma/survival2018.

2. Multiple myeloma

3. New agents in the Treatment of Myeloma Bone Disease

4. Myeloma bone disease: from biology findings to treatment approaches

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