Affiliation:
1. Department of Chemical and Pharmaceutical Sciences University of Trieste Trieste Italy
2. Department for Materials Synthesis Jožef Stefan Institute Ljubljana Slovenia
3. Department of Pharmaceutical Technology, Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia
Abstract
D‐Ser(tBu)‐L‐Phe‐L‐Trp is described as a self‐assembling tripeptide that yields nanofibrillar hydrogels at physiological conditions (phosphate buffer at pH 7.4). The peptide is characterized by several spectroscopic methods, such as circular dichroism and fluorescence, oscillatory rheometry, and transmission electron microscopy. Single‐crystal X‐ray diffraction reveals supramolecular packing into water‐bound channels and allows the visualization of the intermolecular interactions holding together peptide stacks.
Funder
Università degli Studi di Trieste
Javna Agencija za Raziskovalno Dejavnost RS
Subject
Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology
Cited by
6 articles.
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