CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT‐11‐resistant LoVo colon cancer cells via Gαi‐2 and Gαq/11

Author:

Chen Ming‐Cheng123,Baskaran Rathinasamy1ORCID,Lee Nien‐Hung1,Hsu Hsi‐Hsien45,Ho Tsung‐Jung6,Tu Chuan‐Chou7,Lin Yueh‐Min8,Viswanadha Vijaya Padma9,Kuo Wei‐Wen10ORCID,Huang Chih‐Yang1611ORCID

Affiliation:

1. Graduate Institute of Basic Medical Science, China Medical University Taichung Taiwan

2. Department of Surgery, Division of Colorectal Surgery Taichung Veterans General Hospital Taichung Taiwan

3. Faculty of Medicine, National Yang‐Ming University Taipei Taiwan

4. Division of Colorectal Surgery Mackay Memorial Hospital Taipei Taiwan

5. MacKay Medicine, Nursing and Management College Taipei Taiwan

6. Chinese Medicine Department China Medical University Beigang Hospital Yunlin Taiwan

7. Department of Internal Medicine, Division of Chest Medicine Armed Force Taichung General Hospital Taichung Taiwan

8. Department of Pathology Changhua Christian Hospital Changhua Taiwan

9. Department of Biotechnology Bharathiar University Coimbatore India

10. Department of Biological Science and Technology China Medical University Taichung Taiwan

11. Department of Health and Nutrition Biotechnology Asia University Taichung Taiwan

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference55 articles.

1. Mechanisms of chemoresistance in cancer stem cells

2. A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

3. Self-renewal and solid tumor stem cells

4. Temozolomide‐induced modification of the CXC chemokine network in experimental gliomas;Bruyère C.;International Journal of Oncology,2011

5. Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus‐G protein‐coupled receptor;Burger M.;Journal of Immunology,1999

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