Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC ‐driven hepatocellular carcinoma

Author:

Thng Dexter Kai Hao1ORCID,Toh Tan Boon23,Pigini Paolo4,Hooi Lissa15,Dan Yock Young167,Chow Pierce Kah‐Hoe8910,Bonney Glenn Kunnath511,Rashid Masturah Bte Mohd Abdul12,Guccione Ernesto41314,Wee Dave Keng Boon4,Chow Edward Kai‐Hua123515

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore Singapore Singapore

2. The N.1 Institute for Health, National University of Singapore Singapore Singapore

3. The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore Singapore

4. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR) Singapore Singapore

5. NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

6. Division of Gastroenterology and Hepatology National University Health System Singapore Singapore

7. Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

8. Division of Surgical Oncology National Cancer Centre Singapore Singapore Singapore

9. Department of Hepato‐Pancreato‐Biliary and Transplant Surgery Singapore General Hospital Singapore Singapore

10. Duke‐NUS Medical School Singapore Singapore

11. Division of Hepatobiliary and Liver Transplantation Surgery National University Health System Singapore Singapore

12. KYAN Therapeutics Singapore Singapore

13. Department of Oncological Sciences Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai New York New York USA

14. Mount Sinai Center for Therapeutics Discovery, Department of Oncological and Pharmacological Sciences Icahn School of Medicine at Mount Sinai New York New York USA

15. Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biotechnology

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