Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures

Author:

Kim Hyun12ORCID,Lee Seonjoo234,Levine Alina4,Huber Benjamin4,Andrews Howard13,Kerner Nancy A.12,Cohen Daniel2,Carlson Scott2,Bell Sophie A.2,Rivera Andres M.5,Gordon Marc L.6,Simoes Sabrina5,Devanand Davangere. P.125,Brickman Adam M.5,Schneider Lon S.7,Harvey Philip D.8,Goldberg Terry E.129

Affiliation:

1. Department of Psychiatry Columbia University Irving Medical Center New York New York USA

2. Division of Geriatric Psychiatry New York State Psychiatric Institute New York New York USA

3. Department of Biostatistics Mailman School of Public Health Columbia University New York New York USA

4. Division of Mental Health Data Science New York State Psychiatric Institute New York New York USA

5. Department of Neurology Taub Institute for Research in Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA

6. Departments of Neurology and Psychiatry Donald and Barbara Zucker School of Medicine at Hofstra/Northwell The Litwin‐Zucker Research Center Feinstein Institutes for Medical Research Manhasset New York USA

7. University of Southern California Keck School of Medicine Los Angeles California USA

8. University of Miami Miller School of Medicine Miami VA Medical Center Miami Florida USA

9. Department of Anesthesiology Columbia University Irving Medical Center New York New York USA

Abstract

AbstractINTRODUCTIONThis study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early‐stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well‐established measures.METHODSFor 291 older adults with healthy cognition or early mild cognitive impairment, Exploratory factor analyses were used to identify the factor structure of the NPE. Factor and total scores were examined for their psychometric properties and associations with AD risk biomarkers.RESULTSComposite scores from the novel cognitive and functional measures demonstrated better psychometric properties (distribution and test‐retest reliability) and stronger associations with AD‐related demographic, genetic, and brain risk markers than well‐established measures,DISCUSSIONThese novel measures have potential for use as primary cognitive and functional outcomes in early‐stage AD clinical trials.Highlights Well‐established cognitive tests may not accurately detect subtle cognitive changes. No Practice Effect (NPE) and Computerized Functional Skills Assessment and Training are novel measures designed to have improved psychometric properties. NPE had Executive Function, Cognitive Control/Speed, and Episodic Memory domains. Novel measures had better psychometric properties compared to established measures. Significant associations with Alzheimer's disease biomarkers were found with novel measures.

Funder

National Institute on Aging

Publisher

Wiley

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