Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes

Author:

Antoine Lisa H.1,Tanner Jared J.2,Mickle Angela M.34ORCID,Gonzalez Cesar E.1,Kusko Daniel A.1ORCID,Watts Kristen Allen5,Rumble Deanna D.6,Buchanan Taylor L.7,Sims Andrew M.8,Staud Roland9,Lai Song10,Deshpande Hrishikesh11,Phillips Brandis12,Buford Thomas W.1314,Aroke Edwin N.15,Redden David T.8,Fillingim Roger B.316,Goodin Burel R.117,Sibille Kimberly T.34ORCID

Affiliation:

1. Department of Psychology University of Alabama at Birmingham Birmingham Alabama USA

2. Department of Clinical and Health Psychology University of Florida Gainesville Florida USA

3. Pain Research & Intervention Center of Excellence University of Florida Gainesville Florida USA

4. Department of Physical Medicine & Rehabilitation University of Florida Gainesville Florida USA

5. Heersink School of Medicine University of Alabama at Birmingham Birmingham Alabama USA

6. Department of Psychology and Counseling University of Central Arkansas Conway Arkansas USA

7. Center for Exercise Medicine University of Alabama at Birmingham Birmingham Alabama USA

8. Department of Biostatistics University of Alabama at Birmingham Birmingham Alabama USA

9. Department of Medicine University of Florida Gainesville Florida USA

10. Department of Radiation Oncology University of Florida Gainesville Florida USA

11. Department of Radiology University of Alabama at Birmingham Birmingham Alabama USA

12. Department of Accounting & Finance North Carolina A&T State University Greensboro North Carolina USA

13. Department of Medicine − Division of Gerontology, Geriatrics, and Palliative Care University of Alabama at Birmingham Birmingham Alabama USA

14. Birmingham/Atlanta Geriatric Research, Education, and Clinical Center Birmingham VA Medical Center Birmingham Alabama USA

15. School of Nursing University of Alabama at Birmingham Birmingham Alabama USA

16. Department of Community of Dentistry and Behavioral Sciences University of Florida Gainesville Florida USA

17. Department of Anesthesiology Washington University, Washington University Pain Center St. Louis Missouri USA

Abstract

AbstractIntroduction: Previous research indicates ethnic/race group differences in pain and neurodegenerative diseases. Accounting for socioenvironmental factors reduces ethnic/race group differences in clinical and experimental pain. In the current study sample, we previously reported that in individuals with knee pain, ethnic/race group differences were observed in bilateral temporal lobe thickness, areas of the brain associated with risk for Alzheimer's disease, and related dementias. The purpose of the study was to determine if socioenvironmental factors reduce or account for previously observed ethnic/race group differences and explore if a combined effect of socioenvironmental risk and chronic pain severity on temporal lobe cortices is evident.Methods: Consistent with the prior study, the sample was comprised of 147 adults (95 women, 52 men), 45–85 years of age, who self‐identified as non‐Hispanic Black (n = 72) and non‐Hispanic White (n = 75), with knee pain with/at risk for osteoarthritis. Measures included demographics, health history, pain questionnaires, cognitive screening, body mass index, individual‐ and community‐level socioenvironmental factors (education, income, household size, marital and insurance status, and area deprivation index), and brain imaging. We computed a summative socioenvironmental risk index. Results: Regression analyses showed that with the inclusion of socioenvironmental factors, the model was significant (p < .001), and sociodemographic (ethnic/race) group differences were not significant (p = .118). Additionally, findings revealed an additive stress load pattern indicating thinner temporal lobe cortices with greater socioenvironmental risk and chronic pain severity (p = .048).Implications: Although individual socioenvironmental factors were not independent predictors, when collectively combined in models, ethnic/race group differences in bilateral temporal lobe structures were not replicated. Further, combined socioenvironmental risk factors and higher chronic pain severity were associated with thinner bilateral temporal lobes.

Funder

Clinical and Translational Science Institute, University of Florida

Center for Clinical and Translational Science, University of Alabama at Birmingham

National Institute of General Medical Sciences

National Center for Advancing Translational Sciences

National Institutes of Health

Publisher

Wiley

Subject

Behavioral Neuroscience

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