IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey-Reference-Cited by-同舟云学术

IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

Published:2010-02-15 Issue:3 Volume:105 Page:627-635
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Boado Ruben J.,Lu Jeff Zhiqiang,Hui Eric Ka-Wai,Pardridge William M.

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bit.22576/fullpdf

Reference23 articles.

1. Comparison of blood-brain barrier transport of GDNF and an IgG-GDNF fusion protein in the Rhesus monkey;Boado;Drug Metab Disp,2009

2. Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier;Boado;Biotechnol Bioeng,2007

3. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation;Boado;Bioconjug Chem,2007

4. Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier;Boado;Biotechnol Bioeng,2008

5. AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys;Boado;J Biotechnol,2009

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