Affiliation:
1. College of Chemistry and Chemical Engineering Taishan University Tai'an PR China
2. School of Chemistry and Materials Science Jiangsu Normal University, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Xuzhou PR China
Abstract
AbstractIn this research, the multi‐heteroatom heterocycles were effectively obtained via three components reactions from isatins, 3‐aminopyrazol‐5(4H)‐one, and the different heterocyclic ketones (kojic acid, ethyl 4‐oxopiperidine‐1‐carboxylate, and tetrahydro‐4H‐thiopyran‐4‐one) under acetic acid/aqueous condition for the first time. The advantages of the approach were easy to handle, excellent yields, a wide range of substrates and environmental friendliness. This study provided an alternative synthesis pathway for obtaining multi‐heteroatom heterocycle compounds.