Photostability of antidotal oxime HI-6, impact on drug development
Author:
Affiliation:
1. Central Institute of the Bundeswehr Medical Service Munich; Garching Hochbrück; Germany
2. Bundeswehr Institute of Pharmacology and Toxicology; München; Germany
3. Bundeswehr Medical Office; München; Germany
Publisher
Wiley
Subject
Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry
Reference34 articles.
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2. Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats;Kassa;Toxicology,1995
3. Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds;Worek;Arch. Toxicol.,1998
4. Development of the bisquarternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning;Lundy;Toxicol. Rev.,2006
5. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use ICH Harmonised Tripartide Guideline Q1B, Photostability Testing of New Drug Substances and Products 1996
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