Photostability of antidotal oxime HI-6, impact on drug development

Author:

Bogan Reinhard1,Worek Franz2,Koller Marianne2,Klaubert Bernd3

Affiliation:

1. Central Institute of the Bundeswehr Medical Service Munich; Garching Hochbrück; Germany

2. Bundeswehr Institute of Pharmacology and Toxicology; München; Germany

3. Bundeswehr Medical Office; München; Germany

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Reference34 articles.

1. A comparison of the efficacy of HI-6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit;Koplovitz;Toxicol. Lett.,1994

2. Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats;Kassa;Toxicology,1995

3. Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds;Worek;Arch. Toxicol.,1998

4. Development of the bisquarternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning;Lundy;Toxicol. Rev.,2006

5. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use ICH Harmonised Tripartide Guideline Q1B, Photostability Testing of New Drug Substances and Products 1996

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