Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles-Reference-Cited by-同舟云学术

Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

Published:2022-07 Issue:7 Volume:11 Page:
ISSN:2191-1363
Container-title:ChemistryOpen
language:en
Short-container-title:ChemistryOpen

Author:

Xu Hanqiao¹²,Kurohara Takashi¹^ORCID,Takano Reina¹²,Yokoo Hidetomo¹³,Shibata Norihito¹,Ohoka Nobumichi¹,Inoue Takao¹,Naito Mikihiko⁴,Demizu Yosuke¹²^ORCID

Affiliation:

1. National Institute of Health Sciences 3-25-26 Tonomachi Kawasaki Kanagawa 210-9501 Japan

2. Graduate School of Medical Life Science Yokohama City University 1-7-29 Yokohama Kanagawa 230-0045 Japan

3. Medical Chemistry Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto 606-0823 Japan

4. Laboratory of Targeted Protein Degradation Graduate School of Pharmaceutical Sciences The University of Tokyo Tokyo 113-0033 Japan

Funder

Japan Agency for Medical Research and Development

Takeda Science Foundation

Naito Foundation

Sumitomo Foundation

NOVARTIS Foundation (Japan) for the Promotion of Science

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/open.202200131

Reference26 articles.

1. Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

2. PROTACs: An Emerging Therapeutic Modality in Precision Medicine

3. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

4. Current strategies for the design of PROTAC linkers: a critical review

5. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

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