Affiliation:
1. Department of Chemistry University of Malakand 18800 Chakdara, Dir (Lower), Khyber Pakhtunkhwa Pakistan
2. Department of Chemistry College of Science University of Bahrain Main Campus 32038 Sakhir Kingdom of Bahrain
3. Department of Pharmaceutical Chemistry College of Pharmacy King Saud University 11451 Riyadh Saudi Arabia
4. Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province Faculty of Chemical Engineering National and Local Joint Engineering Research Centre for Deep Utilization Technology of Rock-Salt Resource Huaiyin Institute of Technology 223003 Huaian China
Abstract
AbstractIn this study five different complexes of Cu(II) were synthesized for the purpose of environmentally notorious mercury sensing and preliminary biological screening. Pyridine‐2,6‐dicarboxylic acid (also known as dipicolinic acid, and abbreviated as H2DPA), 3‐phenyl pyrazole (3‐ppz), 4‐iodo‐1H‐pyrazole (4‐ipz), 4‐nitropyrazole (4‐npz), 4‐bromopyrazole (4‐bpz), and 4‐chloropyrazole (4‐cpz) were chosen as potential ligands. The synthesized complexes labelled as 1–5, namely [Cu(DPA)(3‐ppz)], [Cu(DPA)(4‐ipz)], [Cu(DPA)(4‐npz)], [Cu(DPA)(4‐bpz)], [Cu(DPA)(4‐cpz)], were proposed based on spectroscopic data (FTIR, TGA, and UV‐visible spectroscopy). These complexes feature C=O functionalities that are not involved in coordination and may be used for further applications. The isolated complexes were utilized for detecting Hg(II) ions in water samples. Various concentrations of Hg(II) ions were prepared for detection purposes, and changes in absorption concerning complexes 1–5 were determined using UV‐Visible spectroscopy. It was found that complexes 3 and 4 exhibit efficient sensing abilities towards Hg(II) ions. The antibacterial activities of complexes 1–5 were assessed against S. typhi and E. coli. The complexes 1 and 3 displayed good antibacterial activities against S. typhi (13.67, and 13.56 mm, respectively) while complexes 1, 2 and 4 were found to be efficient against E. coli (11.6, 12.66, 11.31 mm, respectively). The absorption maxima of 2,2‐diphenyl‐1‐picryhydrazyl (DPPH) at 517 nm, considerably shifted upon addition of complexes 1–5. The results reveal that the complexes possess potential free radical scavenging abilities.