Informing Decisions in Discovery and Early Development Research Through Quantitative and Translational Modeling-Reference-Cited by-同舟云学术

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Informing Decisions in Discovery and Early Development Research Through Quantitative and Translational Modeling

Published:2018-08-03 Issue: Volume: Page:467-496
ISSN:1865-0562
Container-title:Early Drug Development
language:
Short-container-title:

Author:

Bueters Tjerk¹,Gibson Christopher R.¹,Kothare Prajakti A.¹,Lala Mallika¹,Parker Eric M.²,Rizk Matthew L.¹,Tatosian Daniel¹,Trujillo Maria E.¹²,Vaddady Pavan¹,Visser Sandra A.G.¹

Affiliation:

1. Merck & Co., Inc.; Merck Research Laboratories; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism; 2000 Galloping Hill Road Kenilworth NJ 07033 USA

2. Merck & Co., Inc.; Merck Research Laboratories; Department of Pharmacology; 2000 Galloping Hill Road Kenilworth NJ 07033 USA

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/9783527801756.ch17/fullpdf

Reference45 articles.

1. Trends in clinical success rates;Smietana;Nat. Rev. Drug Discov.,2016

2. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival;Morgan;Drug Discovery Today,2012

3. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework;Cook;Nat. Rev. Drug Discov.,2014

4. Translational medicine guide transforms drug development processes: the recent Merck experience;Dolgos;Drug Discovery Today,2016

5. Biomarkers in clinical drug development;Gobburu;Clin. Pharmacol. Ther.,2009

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