Addressing Genotoxicity Risk in Lead Optimization: A PDE10A Inhibitor Case Study-Reference-Cited by-同舟云学术

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Addressing Genotoxicity Risk in Lead Optimization: A PDE10A Inhibitor Case Study

Published:2018-08-03 Issue: Volume: Page:581-602
ISSN:1865-0562
Container-title:Early Drug Development
language:
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Author:

Verbist Bie M. P.¹,Crabbe Marjolein¹,Van Goethem Freddy²,Göhlmann Hinrich W. H.³

Affiliation:

1. Janssen R&D; Statistics and Decision Sciences; Turnhoutseweg 30 2340 Beerse Belgium

2. Janssen R&D; Mechanistic and Investigative Toxicology; Turnhoutseweg 30 2340 Beerse Belgium

3. Janssen R&D; Computational Sciences; Turnhoutseweg 30 2340 Beerse Belgium

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/9783527801756.ch21/fullpdf

Reference40 articles.

1. New drugs cost US2.6 billion to develop;Mullard;Nat. Rev. Drug Discovery,2014

2. Trial watch: phase II and phase III attrition rates 20112012;Arrowsmith;Nat. Rev. Drug Discovery,2013

3. Exploratory toxicology as an integrated part of drug discovery. Part II: screening strategies;Hornberg;Drug Discovery Today,2014

4. Improving the human hazard characterization of chemicals: a Tox21 update;Tice;Environ. Health Perspect.,2013

5. Toxicity testing in the 21st century beyond environmental chemicals;Rovida;ALTEX,2015

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