The Discovery of Obeticholic Acid (Ocaliva™): First-in-Class FXR Agonist-Reference-Cited by-同舟云学术

The Discovery of Obeticholic Acid (Ocaliva™): First-in-Class FXR Agonist

Published:2018-04-16 Issue: Volume: Page:197-244
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Container-title:Successful Drug Discovery
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Author:

Pellicciari Roberto¹,Pruzanski Mark²,Gioiello Antimo³

Affiliation:

1. TES Pharma; Corso Vannucci 47 06121 Perugia Italy

2. Intercept Pharmaceuticals; 450 W 15th Street New York NY 10001 USA

3. University of Perugia; Department of Pharmaceutical Sciences; Via del Liceo 1 06122 Perugia Italy

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Reference141 articles.

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3. Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids;Natalini;Anal. Bioanal. Chem.,2007

4. Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids;Natalini;J. Pharm. Biomed. Anal.,2009

5. Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC;Roda;J. Lipid Res.,1990

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