Opicapone, a Novel Catechol-O -Methyltranferase Inhibitor (COMT) to Manage the Symptoms of Parkinson's Disease

Author:

Kiss László E.1,Bonifácio Maria João2,Rocha José Francisco3,da-Silva Patrício Soares-45

Affiliation:

1. BIAL - Portela & C ., S.A.; Department of Research & Development, Laboratory of Chemistry; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão e S. Mamede) Portugal

2. BIAL - Portela & C ., S.A.; Department of Research & Development, Laboratory of Pharmacology; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão e S. Mamede) Portugal

3. BIAL - Portela & C ., S.A.; Department of Research & Development, Clinical Research Unit; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão e S. Mamede) Portugal

4. BIAL - Portela & C ., S.A.; Department of Research & Development; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão e S. Mamede) Portugal

5. MedInUP - Center for Drug Discovery and Innovative Medicines; University of Porto; Portugal

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Reference42 articles.

1. Epidemiology of Parkinson's disease;de Lau;Lancet Neurol.,2006

2. The prevalence of Parkinson's disease: a systematic review and meta-analysis;Pringsheim;Mov. Disord.,2014

3. Mitochondrial involvement in Parkinson's disease;Orth;Neurochem. Int.,2002

4. Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system;Ehringer;Klin. Wochenschr.,1960

5. Monoamine oxidase and catecholamine metabolism;Kopin;J. Neural Transm. Suppl.,1994

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