Recent advances of aggregation‐induced emission in body surface organs

Author:

Li Hang12,Zhang Tingting12,Liao Yingying3,Liu Chutong3,He Yisheng4,Wang Yongfei4,Li Conglei4,Jiang Cheng4,Li Chenzhong4,Luo Guanghong5,Xiang Zhongyuan12,Duo Yanhong6ORCID

Affiliation:

1. Department of Laboratory Medicine The Second Xiangya Hospital Central South University Changsha China

2. Department of Pharmacy The Second Xiangya Hospital Central South University Changsha China

3. The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen China

4. School of Medicine The Chinese University of Hong Kong (Shenzhen) Shenzhen China

5. Department of Radiation Oncology Shenzhen People's Hospital (The Second Clinical Medical College The First Affiliated Hospital Jinan University Southern University of Science and Technology) Shenzhen China

6. Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Science Harvard University Boston Massachusetts USA

Abstract

AbstractThe surface organs mainly comprise the superficial layers of various parts of the mammalian body, including the skin, eyes, and ears, which provide solid protection against various threats to the entire body. Damage to surface organs could lead to many serious diseases or even death. Currently, despite significant advancements in this field, there remain numerous enigmas that necessitate expeditious resolution, particularly pertaining to diagnostic and therapeutic objectives. The advancements in nanomedicine have provided a significant impetus for the development of novel approaches in the diagnosis, bioimaging, and therapy of superficial organs. The aggregation‐induced emission (AIE) phenomenon, initially observed by Prof. Ben Zhong Tang, stands out due to its contrasting behavior to the aggregation‐caused quenching effect. This discovery has significantly revolutionized the field of nanomedicine for surface organs owing to its remarkable advantages. In this review of literature, we aim to provide a comprehensive summary of recent advances of AIE lumenogen (AIEgen)‐based nanoplatforms in the fields of detection, diagnosis, imaging, and therapeutics of surface organ‐related diseases and discuss their prospects in the domain. It is hoped that this review will help attract researchers’ attention toward the utilization of this field for the exploration of a wider range of biomedical and clinical applications.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Medicine,General Chemistry

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