Crystallographic, Spectroscopic, and Theoretical Investigation of the Efficiently Separated 21R and 21S -Diastereoisomers of Argatroban

Author:

Ferraboschi Patrizia1,Colombo Diego1,Legnani Laura1,Toma Lucio2,Grisenti Paride3,Vistoli Giulio4,Meneghetti Fiorella4

Affiliation:

1. Dipartimento di Biotecnologie Mediche e Medicina Traslazionale; Università degli Studi di Milano; Milano Italy

2. Dipartimento di Chimica Università degli Studi di Pavia; Pavia Italy

3. EUTICALS SpA; Rozzano (MI) Italy

4. Dipartimento di Scienze Farmaceutiche; Università degli Studi di Milano; Milano Italy

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference41 articles.

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3. Protease inhibitors in the clinic;Abbenante;Med Chem,2005

4. Thrombin inhibitor design;Sanderson;Curr Med Chem,1998

5. Progress in the development of synthetic thrombin inhibitors as new orally active anticoagulants;Steinmetzer;J Curr Med Chem,2004

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