Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218

Author:

Deyell Rebecca J.1ORCID,Wu Bing2,Rassekh S. Rod1,Tu Dongsheng3,Samson Yvan4,Fleming Adam5,Bouffet Eric2,Sun Xiaoqun3,Powers Jean3,Seymour Lesley3,Baruchel Sylvain2,Morgenstern Daniel A.2ORCID

Affiliation:

1. Division of Pediatric Hematology/Oncology/BMT; University of British Columbia; British Columbia Children's Hospital and Research Institute; Vancouver British Columbia Canada

2. Department of Pediatrics; University of Toronto and New Agent and Innovative Therapy Program; The Hospital for Sick Children; Toronto Ontario Canada

3. Canadian Cancer Trials Group and Queen's University; Kingston Ontario Canada

4. Centre Hospitalier Universitaire Sainte-Justine; Montreal Quebec Canada

5. McMaster Children's Hospital at Hamilton Health Sciences; Hamilton Ontario Canada

Funder

Canadian Cancer Trials Group

Garron Family Cancer Centre

SickKids Foundation,

Great Cycle Challenge Canada

Canadian Cancer Society Research Institute

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference35 articles.

1. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition;Dudkin;Clin Cancer Res,2001

2. Insulin-like growth factor binding protein-6 and CCI-779, an ester analogue of rapamycin, additively inhibit rhabdomyosarcoma growth;Gallicchio;Horm Metab Res,2003

3. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells;Hosoi;Cancer Res,1999

4. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo;Johnsen;Oncogene,2008

5. Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors;Spunt;J Clin Oncol,2011

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